????????? ???????? ?? ?? ??? ?? ????????? ??? ??????????????? ????????????? ????? ???????? ??? ???? ?? ???????? ???? ?????.Tadalafil is fourteen-fold additional strong for PDE5 than for PDE11A1 and 40-fold far more potent for PDE5 than for PDE11A4, two on the four recognised varieties of PDE11. PDE11 is an enzyme located in human prostate, testes,